Recent Selected Publications

  • Senna GW, Dantas EHM, Scudese E, Brandao PP, Lira VA, Baffi M, Ribeiro LCP, Simao R, Thomas E, Bianco A. Higher Muscle Damage Triggered by Shorter Inter-Set Rest Periods in Volume-Equated Resistance Exercise. Front Physiol 2022 Feb 28:827847.

  • Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA. Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. Autophagy 2022 Feb 1:1-17.

  • Lamin V, Verry J, Eigner-Bybee I, Fuqua JD, Wong T, Lira VA, Dokun AO. Modulation of miR-29a and ADAM12 reduces post-ischemic skeletal muscle injury and improves perfusion recovery and skeletal muscle function in a mouse model of type 2 diabetes and peripheral artery disease. Int J Mol Sci 2021 23(1):429.

  • Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, Li W, Zingman LV, Liu L, Lira VA, Potthoff MJ, Bartelt A, Yang L. ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. Cell Reports 2021 37(7):110003.

  • Morales PE, Monsalvez-Alvarez M, Tadinada SM, Harris MP, Ramirez-Sagredo A, Ortiz-Quintero J, Troncoso MF, De Gregorio N, Calle X, Pereira RO, Lira VA, Espinosa A, Abel ED, Levandero S. Skeletal muscle type-speficic mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. FASEB J 2021 35(10):e21933.

  • Bhardwaj G, Penniman CM, Jena J, Suarez Bestran PA, Foster C, Poro K, Junck TL, Hinton AO Jr, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest 2021 131(18):e146415.

  • Okutsu M, Yamada M, Tokizawa K, Marui S, Suzuki K, Lira VA, Nagashima K. Regular exercise stimulates endothelium autophagy via IL-1 signaling in ApoE deficient mice. FASEB J 2021 35(7):e21698.

  • Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S,......, Lira VA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021 17(1):1-382.

  • de Sousa LGO, Marshall AG, Normal JE, Fuqua JD, Lira VA, Rutlege JC, Bodine SC. The effects of diet composition and chronic obesity on muscle growth and function. J Appl Physiol 2021 130(1):124-138.

  • Zhang Z, Qia Q, Li M, Shao F, Ding W-X, Lira VA, Chen SX, Sebag SC, Hotamisligil GS, Cao H, Yang L. The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB. Autophagy 2021, 17(8):1841-1855.

  • Yamada M, Hokazono C, Tokiazawa K, Marui S, Iwata M, Lira VA, Suzuki K, Miura S, Nagashima K, Okutsu M. Muscle-derived SDF-1a/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. Am J Physiol Regul Integr Comp Physiol 2019, Dec 1;317(6):R770-R779.

  • Fuqua JD, Mere CP, Kronemberger A, Blomme J, Bae D, Turner KD, Harris MP, Scudese E, Edwards M, Ebert SM, de Sousa LGO, Bodine SC, Yang L, Adams CM, Lira VA. ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle. FASEB J 2019, Nov; 33(11):11735-11745.

  • Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J 2019, Jul;33(7):8022-8032.

  • Stauss HM, Stangl H, Clark KC, Kwitek AE, Lira VA. Cervical vagal nerve stimulation impairs glucose tolerance and suppresses insulin release in conscious rats. Physiol Rep 2018, Dec;6(24):e13953. 

  • Boland L, Burand AJ, Brown AJ, Boyt D, Lira VA, Ankrum JA. IFN-y and TNF-a pre-licensing protets mesenchymal stromal cells from the pro-inflammatory effects of palmitate. Mol Ther 2018, Mar 7;26(3):860-873. 

  • Turner JE, Lira VA, Brum PC. New insights into the benefits of physical activity and exercise for aging and chronic disease. Oxid Med Cell Longev 2017, doi: 10.1155/2017/2503767. 

  • Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchk O, Schaffer JE, Abel ED. Mitochondrial reactive oxygen species in lipotoxic hearts induces post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission. Circ Res 2018, Jan 5;122(1):58-73. 

  • Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z. Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Rad Biol Med 113:212-223, 2017.    

  • Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan Z. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun 8(1):548, 2017. 

  • Yan Z, Kronemberger A, Blomme J, Call JA, Caster HM, Pereira RO, Zhao H, de Melo VU, Laker RC, Zhang M, Lira VA. Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency. Sci Reports 7(1):7894, 2017.   

  • De Melo VU, Saldanha RR, Dos Santos CR, De Campos Cruz J, Lira VA, Santana-Filho VJ, Michelini LC. Ovarian hormone deprivation reduces oxytocin expression in paraventricular nucleus preautonomic neurons and correlates with baroreflex impairment in rats. Front Physiol Oct 13;7:461, 2016.

  • Patel DI, White LJ, Lira VA, Criswell DS. Forced exercise increases muscle mass in EAE despite early onset of disability. Physiol Res. Dec 13;65(6):1013-1017, 2016.

  • Meyers EE, Kronemberger A, Lira V, Rahmouni K, Stauss HM. Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation. Physiol Rep 4(4) pii12718, 2016.

  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A,......, Lira VA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016.

  • Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. Identification and small molecule inhibition of ATF4-dependent pathway to age-related skeletal muscle weakness and atrophy. J Biol Chem 29(42):25498-511, 2015. 

  • Chao H, Li H, Grande R, Lira V, Yan Z, Harris TE, Li C. Involvement of mTOR in type 2 CRF receptor inhibition of insulin signaling in skeletal muscle cells. Mol Endocrinol 29(6):831-841, 2015. 

  • Cohen TJ, Choi MC, Kapur M, Lira VA, Yan Z, Yao TP. HDAC4 regulates muscle fiber-type specific gene expression programs. Mol Cells 38(4):343-348, 2015.

  • Lira VA. Exercise-induced cardioprotection: More to k‘NO’w. Cardiology 130(3):172-174, 2015.

  • Call JA, Chain KH, Martin KS, Lira VA, Okutsu M, Zhang M, Yan Z. Enhanced skeletal muscle expression of EcSOD mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. Circ Heart Fail 8(1):188-97, 2015.

  • Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Pierce-Cottler SM, Rembold CM, Annex BH, Yan Z. Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure. Circ Heart Fail 7(3):519-30, 2014.

  • Okutsu M, Lira VA, Higashida K, Peake J, Higushi M, Suzuki K. Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Atherosclerosis 232(2):414-9, 2014.

  • Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J 27(10):4184-93, 2013.

  • Soltow QA, Zeanah EH, Lira VA, Criswell DS. Cessation of cyclic stretch induces atrophy of C2C12 myotubes. Biochem Biophys Res Commun 434(2):316-21, 2013.

  • Yan Z, Lira VA, Greene NP. Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev 40(3):159-64, 2012.

  • Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. Free Radic Biol Med 52(9):1708-15, 2012.

  • Yan Z, Okutsu M, Akhtar YN, Lira VA. Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol 110(1):264-74, 2011.

  • Soltow QA, Lira VA, Betters JL, Long JH, Sellman JE, Zeanah EH, Criswell DS. Nitric oxide regulates stretch-induced proliferation in C2C12 myoblasts. J Muscle Res Cell Motil 31(3):215-25, 2010.

  • Lira VA, Brown DL, Lira AK, Kavazis AN, Soltow QA, Zeanah EH, Criswell DS. Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells. J Physiol 588(Pt 18):3551-66, 2010.

  • Lira VA, Benton CR, Yan Z, Bonen A. PGC-1{alpha} regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab 299(2):E145-61, 2010.

  • Pogozelski AR, Geng T, Li P, Yin X, Lira VA, Zhang M, Chi JT, Yan Z. p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One 4:e7934, 2009.

  • Lira VA, Soltow QA, Long JH, Betters JL, Sellman JE, Criswell DS. Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle. Am J Physiol Endocrinol Metab 293(4):E1062-8, 2007.