Mission Statement

Skeletal muscle function is a key determinant of health span and quality of life at all ages. Our major goal is to identify molecular targets to preserve skeletal muscle contractile and metabolic functions throughout life. More specifically, studies in the lab focus on determining the mechanisms involved in skeletal muscle dysfunction in disuse (e.g., immobilization and hospitalization), sarcopenia, diabetes, and heart failure. Intracellular and cross-tissue pathways responsible for the beneficial effects of exercise are also of major interest. We conduct pre-clinical studies primarily combining unbiased approaches (e.g., proteomics, metabolomics) with molecular biology and mouse genetics.