Mission Statement

Our overarching goal is to use exercise and calorie restriction as physiological models to discover novel therapeutic targets for the treatment of obesity, diabetes, and associated cardiovascular diseases.

Skeletal muscle and heart metabolism are often compromised in obesity and diabetes resulting in skeletal muscle insulin resistance and diabetic cardiomyopathy.

Exercise and calorie restriction are among the most effective and frequently used interventions to improve skeletal muscle insulin sensitivity, and to provide cardioprotection; however the cellular and molecular mechanisms involved remain incompletely understood.

We use an integrative approach to address these questions combining mouse genetics with functional assays and state-of-the-art molecular tools.